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IECs, intestinal epithelial cells

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ser-7 acts in the MC and M4 enteric neurons to promote feeding or recognition of familiar food 10,21 , but expression in these neurons did not rescue aversion to the mediocre crp diet, nor did expression in I1 neuron rescue ser-7 feeding, indicating that aversion and feeding are separable functions of ser-7 (Fig

They also reduce hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting hepatic sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"